The finding of a new mechanism that controls the way nerve cells in the brain correspond with each other to manage our learning and long-term memory could have major benefits to understanding how the brain works and what goes wrong in neurodegenerative disorders such as epilepsy and dementia. The breakthrough was made by scientists at the University of Bristol and the University of Central Lancashire. The discovery will have far-reaching significance in many aspects of neuroscience.
The human brain contains around 100-billion nerve cells, each of which makes about 10,000 networks to other cells, called synapses. Synapses are constantly sending data to, and receiving data from other nerve cells. A process, called long-term potentiation (LTP), increases the strength of data flow across synapses. A lot of synapses communicating between different nerve cells form networks and LTP intensifies the connectivity of the cells in the network to make data transfer more adequate. This LTP mechanism is how the brain operates at the cellular level to allow us to learn and remember. However, when these processes go wrong they can lead to neurological disorders.
Exactly how LTP is initiated is a major question in neuroscience. Conventional LTP is regulated by the activation of distinct proteins at synapses called NMDA receptors. This study reports a new type of LTP that is controlled by kainate receptors. This is a significant advance as it highlights the flexibility in the way synapses are regulated and nerve cells correspond. This heightens the possibility of targeting this new pathway to develop therapeutic strategies for diseases like dementia, in which there is too little synaptic transmission and LTP, and epilepsy where there is too much inappropriate synaptic transmission and LTP.
Jeremy Henley, Professor of Molecular Neuroscience in the University’s School of Biochemistry in the Faculty of Medical and Veterinary Sciences said, “These discoveries represent a significant advance and will have far-reaching implications for the understanding of memory, cognition, developmental plasticity and neuronal network formation and stabilisation. In summary, we believe that this is a groundbreaking study that opens new lines of inquiry which will increase understanding of the molecular details of synaptic function in health and disease.”
Dr Milos Petrovic, co-author of the study and Reader in Neuroscience at the University of Central Lancashire stated, “Untangling the interactions between the signal receptors in the brain not only tells us more about the inner workings of a healthy brain, but also provides a practical insight into what happens when we form new memories. If we can preserve these signals it may help protect against brain diseases.”
Petrovic also said, “This is certainly an extremely exciting discovery and something that could potentially impact the global population. We have discovered potential new drug targets that could help to cure the devastating consequences of dementias, such as Alzheimer’s disease. Collaborating with researchers across the world in order to identify new ways to fight disease like this is what world-class scientific research is all about, and we look forward to continuing our work in this area.”