Repositive Partners with AstraZeneca to Further Research on Oncology


    Repositive, in collaboration with AstraZeneca, has developed a platform to provide access to molecular data for research on oncology. The data was taken from Patient Derived Xenographs (PDXs). Repositive is a software company and has been working on developing novel tools to give increased access to human

    genomic data and also a consortia project, and that is why it is collaborating with AstraZeneca.
    The CEO of Repositive Fiona Nielsen explained the tricky and costly method of deriving PDXs. She stated that PDXs are derived by transplanting a cancer-causing tissue from a patient to an immunodeficient mouse. However, people conducting research on cancer give preference to PDXs instead of cancer cell lines the tumors are not exposed to stimuli, genetic evolution and selective pressures that are a consequence of cell culturing process.

    According to Nielsen, those companies who have specialization in developing models of mice provide the PDXs models. If AstraZeneca has to figure out which models to use, they would individually have to go to each of the vendors of PDXs and ask them separately about the different types of mutations as well as data on different types of models.

    Nielsen added that this load has been taken by Repositive’s consortiu, while compiling and arranging all of the PDX data into a single database that would be user friendly. She explained further that each of the researchers have to research about every PDX vendor there is and figure out what they require as per their need.

    The PDX database is expected to be a platform where much better access to human genomic data will be provided. The date for the launch of the database is September 01. In a press release, Nielsen said that they were glad that Repositive skills were being applied in data sourcing as well as web application development in order to give instant benefits to the consortia partners.

    Nielsen further added that the public platform by Repositive will be free to search. She was of the view that while anyone’s average researcher may know around six public repositories to search around for things, they had more than 270.


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