Nanoparticles From Pollution May Cause Diseases

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You won’t breathe easy after reading this: a few of the nanoparticles in the air you are inhaling are entering your bloodstream and building up in the diseased areas of your arteries.

This finding could help explain why air pollution raises the risk of heart disease and strokes.

What’s really worrying is that it suggests that current laws and efforts to regulate air pollution are focusing on the wrong particles.

“We are potentially looking in the wrong place,” says David Newby at the University of Edinburgh, UK. Numerous studies have shown that air pollution leads to millions of premature deaths worldwide each year.

Even in Europe, with its relatively clean air, air pollution is blamed for 400,000 premature deaths a year.

Most of these deaths are due to the raised risk of cardiovascular disease: simply being exposed to high pollution for short periods can trigger heart attacks and strokes, while long-term exposure causes vascular damage.

It has long been suspected that some of the nanoparticles we breathe in could get into the bloodstream and damage blood vessels, but until now, this had never been shown.

These nanoparticles are mostly carbon compounds, and finding them inside carbon-based lifeforms like ourselves is extremely difficult.

Artery plaques So the team instead got volunteers to breathe air filled with harmless gold nanoparticles.

Within 15 minutes the nanoparticles began to show up in the volunteer’s blood – and they could still be found in blood and urine three months later.

“We were really surprised that levels were so high three months afterwards,” says team leader Mark Miller, also at Edinburgh.

Next the team got a few people who were due to undergo surgery to breathe in the gold nanoparticles.

They found that when nanoparticles get into the body, they accumulate in the fatty plaques that can grow inside arteries, causing heart attacks and strokes.

While gold nanoparticles are inert, the reactive compounds found in air pollution could have all sorts of harmful effects, from impairing the contraction of blood vessels to promote clotting, Miller says.

The study goes a long way towards explaining how air pollution causes vascular injury and disease, says Frank Kelly at King’s College London.

“If these findings with gold particles reflect the movement of exhaust-generated carbon particles, then the increased production of very small particles by modern engines is a cause for further concern,” he said in a statement.

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