Medical Break Throughs In 2018


Things move fast in the world of modern medicine, but if expert predictions about what to expect in 2018 prove true, they might move at a quicker speed than anyone anticipated.

It could also see technology companies start to become as important a player in the health-care world as pharmaceutical companies. Breakthroughs in everything from patient monitoring to sleep apnea are coming from Silicon Valley and could dramatically shift the current paradigm.

The Cleveland Clinic, for the past 10 years, has put together an annual list of expected medical innovations for the coming year. In that time, says Chief Wellness Officer Dr. Michael Roizen, who leads the initiative, the group has truly missed only one prediction. While the group has occasionally been a bit premature in some of its estimates, he says, the predictions have ultimately come true.

To make the predictions, the group interviews more than 150 physicians, 30 to 40 venture capitalists and a handful of media who cover the medical industry across the country to get their collective thoughts on what’s imminent. That list is then honed, eliminating long-shot candidates, and goes through a double-elimination vote among physicians and venture capitalists. Nominees are thoroughly vetted, and the groups eliminate candidates throughout the process.

Here’s some of what the group expects to see this year.

In a historic move, the FDA has approved gene therapy for inherited retinal diseases. The approval signals a new era for gene therapy, which suffered setbacks for years but is now pressing forward.

Patients that have a defective gene called RPE65 — which is responsible for producing a protein that makes light receptors in the eye — suffer from leber congenital amaurosis and retinitis pigmentosa, yet now have hope.

The treatment made by Spark Therapeutics is called Luxturna. It is injected into the eye and uses a benign virus to deliver healthy copies of the gene to the retina.

While not a cure, it can improve eyesight substantially, according to researchers. But it comes with a whopping price tag: $850,000 per onetime treatment.

This breakthrough can be a big first step in medicine. “If you look at cancer, we know the majority of cancer starts with a DNA defect,” Dr. Roizen says. “And that DNA defect can be corrected or ameliorated. Say you have a family who has in vitro fertilization; they will examine the genes of the embryo before it gets implanted to see if it has any problems — and if so, can we intervene and change that problem? … This has a huge potential that is just going to start to break through.”

The Cleveland Clinic’s not the only group that’s bullish on gene therapy. Health24 listed it as one of the 10 advancements to expect this year as well.

Big reductions in LDL cholesterol

Bad cholesterol, known as low-density lipoprotein (LDL), is a major factor in heart disease. And certain new drug combinations can lower LDL levels by 75 percent. PCSK9 inhibitors, along with statins, have proved especially powerful at reducing bad cholesterol numbers. That, says Roizen, could also help people truly change their lifestyles to focus more on healthy living.

A number of trials are testing this theory now to see just how low LDL levels should go. Doctors now have the tools and research to help reduce cardiovascular death.

A new kind of patient monitoring

Part of the reason an intensive care unit is so chaotic is because alarms are constantly going off — and they’re not always critical. (One study, says Roizen, found that 80 percent of hospital alarms were deemed unnecessary.)

Big data is starting to inch its way into the hospital and this year could be a turning point, as “mission control” operations monitor those alarms and alert staff when things require intervention. Those stations can spot trends that harried health-care employees can’t as they rush from crisis to crisis. And using artificial intelligence algorithms, they can predict which patients will get in trouble and let doctors and nurses intervene, ideally before it becomes critical.

Similarly, hospitals are discharging patients quicker than ever these days. But follow-up appointments with doctors can be challenging — and are certainly inconvenient since the patient has to drive (or be driven) to the doctor’s office for what often amounts to a five-minute appointment.

“Well over 80 percent of our post-op patients now see their surgeon every day via … an app on the iPhone, where they can show the wound and talk to the doctor,” says Roizen. “It’s an ease of convenience so the patient doesn’t have to come in for the one-week checkup. Instead, they can be seen every day.”


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