Gene Therapy as an Option for Cancer Treatment

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A team of University of Toronto researchers has worked through the humangenome, switching off genes in an effort to map out those essential in keepingour cells alive.

The scientists were able to identify sets of genes associated with specific cancers, paving the way for highly targeted treatments.

While mapping the human genome was a huge step forward, actuallyunderstanding and there for being able to manipulate the function of each individual gene is extremely difficult.

In order to work out the individual functions of each of the thousands of genesscientists switch off genes one-by-one, gauging what happens to the cell as result.

Early attempts to do this were very slow or too inaccurate to be practical, but amore effective gene editing tool was introduced in 2012, known as CRISPRwhich has made the process much quicker and more accurate.

The University of Toronto team decided to look at the big picture, switching offclose to 18,000 genes a number that represents 90 percent of the entirehuman genome.

They eventually isolated just 1,500 genes that are essential to keeping our cells alive.

Digging deeper, the researchers turned off genes associated with five differentcancer cell lines brain, ovarian, retinal and two forms of colorectal cancer establishing that the different tumors rely on specific and unique sets of genes.

The research is a big step forward in humanity’s overall understanding of how our genome works, and puts us closer than ever to achieving the ultimate goal of identifying the function of every single gene.

We can now interrogate our genome at unprecedented resolution in humancells that we grow in the lab with incredible speed and accuracy,” says theUniversity of Toronto’s Prof. Jason Moffat.

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