According to data that was published in Nutrients, increasing your coffee intake is connected with a lower risk of liver cancer, though there is no evident connection between coffee consumption and risk of biliary tract cancer.
Justyna Godos, MSc, from the Department of Medical and Surgical Sciences and Advanced Technologies at the University of Catania located in Catania, Italy, and colleagues under went a meta-analysis that entailed 5 studies observing the risk of biliary tract cancer and 13 studies on liver cancer risk. The researchers evaluated the dose-response relationship with a limited cubic spline model and multivariate random-effect meta-regression.
The results displayed no noteworthy relationship between coffee consumption and the risk of biliary tract cancer, though, there was evidence of an inverse association between coffee intake and liver cancer risk. The connection was consistent when noting potential confounding factors, such as hepatitis and smoking status.
The researchers reported that advancing coffee consumption by 1 cup per day was connected with a 15 percent reduced risk of liver cancer. In comparison with participants who were not coffee drinkers, the relative risks for liver cancer were 0.82 for 1 cup of coffee per day, 0.68 for 2 cups per day, 0.57 for 3 cups daily, 0.47 for 4 cups of coffee daily, 0.39 for 5 cups per day, 0.33 for 6 cups of coffee per day, and 0.27 for 7 cups of coffee per day.
“Coffee may represent a valid functional food for liver protection,” the authors of the study reported. “Current evidence is sufficient to guide future clinical randomized trials to test the hepatoprotective effects of coffee, which in turn may lead to more definitive recommendations. However, further observational studies with better in depth analyses of potential confounding factors are needed to test the association between coffee consumption and [biliary tract cancer].”