Celgene Corporation (CELG) Announces Clinical Data Evaluating Broad Range of Blood Cancers

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Celgene Announces Clinical Data Evaluating Broad Range of Blood Cancers to Be Presented at EHA 2017

Celgene Corporation (CELG) today announced that data from a broad range of company-sponsored and investigator-initiated studies evaluating Celgene investigational agents and investigational uses of marketed products will be presented at the 22nd European Hematology Association annual meeting in Madrid, Spain, from June 22-25, 2017.

“Research into blood cancers is at a pivotal point, where we’re able to apply insights into the biology of disease to help evolve the treatment pathways, as well as continue to deepen our understanding of the disease in ways that have the potential to positively impact patients’ lives,” said Michael Pehl, President, Hematology and Oncology for Celgene. “The studies being shared this year illustrate our ongoing commitment to delivering innovative therapies to patients with serious and sometimes underserved blood cancers.”

This year’s data presented at EHA will support the role of Celgene therapies as the foundation of myeloma research, including data evaluating REVLIMID® (lenalidomide) across a variety of patient settings ranging from newly diagnosed to those receiving maintenance treatment following autologous hematopoietic stem cell transplant. The data also highlight the potential of Celgene treatments across a range of blood cancers such as lymphoma, MDS and beta-thalassemia. Findings from key Celgene research collaborations will also be presented, including updated data from the Phase I dose escalation and expansion study of IDHIFA® (enasidenib) in patients with relapsed/refractory acute myeloid leukemia and an isocitrate dehydrogenase-2 mutation.

Selected abstracts include:

Newly-Diagnosed Multiple Myeloma

Abstract #S102; Oral; Friday, June 23, 12:00 p.m., Hall A. Minimal Residual Disease (MRD) by Multiparameter Flow Cytometry (MFC) in Transplant Eligible Patients with Newly Diagnosed Multiple Myeloma (MM): Results from the EMN02/HO95 Phase 3 Trial (Oliva)

Abstract #S407; Oral; Saturday, June 24, 11:30 a.m., Hall A. Quadruplet vs. Sequential Triplet Induction Therapy for Multiple Myeloma Patients: Results of the MYELOMA XI Study (Pawlyn)

Abstract #S410; Oral; Saturday, June 24, 12:15 p.m., Hall A. Carfilzomib-Lenalidomide-Dexamethasone vs. Carfilzomib-Cyclophosphamide-Dexamethasone Induction: Planned Interim Analysis of the Randomized Forte Trial in Newly Diagnosed Multiple Myeloma (Gay)

Abstract #P349; Poster Discussion; Friday, June 23, 5:15 p.m., Hall 7. The Connect MM Registry: Impact of the Cytogenic Abnormality (11;14) on Survival Outcomes in African American and non-African American Patients with Newly Diagnosed Multiple Myeloma (Gasparetto)

Relapsed/Refractory Multiple Myeloma

Abstract #S142; Oral; Friday, June 23, 11:45 a.m., Room N109. First-in-Human Multicenter Study of BB2121 Anti-BCMA CAR T Cell Therapy for Relapsed/Refractory Multiple Myeloma: Updated Results (Lin)

Abstract #S456; Oral; Saturday, June 24, 4:00 p.m., Hall A. Phase 3 ELOQUENT-2 Study: Extended 4-Year Follow-up of Elotuzumab plus Lenalidomide/Dexamethasone vs. Lenalidomide/Dexamethasone in Relapsed/Refractory Multiple Myeloma (Dimopoulos)

Abstract #P343; Poster Presentation; Friday, June 23, 5:15 p.m., Hall 7. MM-013 Phase 2 Multicenter Study of Pomalidomide (POM) plus Low-dose Dexamethasone (LODEX) in Patients (PTS) with Relapsed/Refractory Multiple Myeloma (RRMM) and Renal Impairment (RI) (Sonneveld)

Abstract #P680; Poster Presentation; Saturday, June 24, 5:30 p.m., Hall 7. Final Results of Phase (PH) 1/2 Study of Carfilzomib, Pomalidomide, and Dexamethasone (KPD) in Patients (PTS) with Relapsed/Refractory Multiple Myeloma (RRMM): A Multi-Center MMRC Study (Jakubowiak)

Maintenance in Multiple Myeloma

Abstract #S781; Oral; Sunday, June 25, 8:30 a.m., Hall D. Lenalidomide Induction and Maintenance Therapy for Transplant Eligible Myeloma Patients: Results of the MYELOMA XI Study (Pawlyn)

Abstract #P332; Poster Discussion; Friday, June 23, 5:15 p.m., Hall 7. Lenalidomide Maintenance vs. Placebo After Stem Cell Transplant for Patients with Multiple Myeloma: Overall Survival and Progression-free Survival After Adjusting for Treatment Crossover in CALGB (McCarthy)

Acute Myeloid Leukemia

Abstract #S471; Oral; Saturday, June 24, 4:00 p.m., Hall D. Enasidenib (AG-221) in Mutant-IDH2 Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): Results of a Phase 1 Dose-escalation and Expansion Study (Stein)

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