Aratana Therapeutics, Inc. (PETX) Granted Conditional License for a Canine Osteosarcoma Therapeutic

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Aratana Therapeutics Granted Conditional License for a Canine Osteosarcoma Therapeutic

“Osteosarcoma is the most common primary bone tumor in dogs and, since there haven’t been advances to raise the standard of care in nearly 20 years, dogs often face a poor prognosis,” states Ernst Heinen, DVM, PhD, Chief Development Officer of Aratana Therapeutics. “We are hopeful that our Canine Osteosarcoma Vaccine will be a new tool for veterinary oncologists to prolong survival in dogs with osteosarcoma.”

Canine Osteosarcoma Vaccine is a novel immunotherapy developed by Aratana using a listeria based antigen delivery system licensed from Advaxis, Inc. (ADXS). Canine Osteosarcoma Vaccine is a lyophilized formulation of a modified live, attenuated strain of listeria that activates cytotoxic T-cells. Because the therapeutic expresses a tumor-associated antigen, it directs the T-cells to fight cancer cells, even after the bacteria are cleared. Thus, the therapeutic capitalizes on the dog’s immune system and its ability to attack bacterial infections, redirecting it to fight cancer cells.

Data from a clinical study in 18 client-owned dogs with osteosarcoma suggests that the immunotherapy may be able to delay or prevent metastatic disease and may prolong overall survival in dogs with osteosarcoma. The single-arm study evaluated dogs that had primary tumor removal and four doses of carboplatin chemotherapy, followed by the therapeutic vaccine every three weeks for three doses. Median survival time was 956 days compared to 423 days for a historical control group (p<0.05). A separate field safety study submitted to USDA for conditional licensure demonstrated that the most common adverse events included lethargy, diarrhea and fever. Four serious adverse events were observed.

As required by USDA to progress from conditional licensure to full licensure, Aratana plans to conduct an extended field study in a clinical setting and anticipates initiating the study in early 2018. Initially, the therapeutic will be made available for purchase at approximately two dozen veterinary oncology practice groups across the United Stateswho participate in the study.

About Aratana Therapeutics
Aratana Therapeutics is a pet therapeutics company focused on licensing, developing and commercializing innovative therapeutics for dogs and cats. Aratana believes that it can leverage the investment in the human biopharmaceutical industry to bring therapeutics to pets in a capital and time efficient manner. The Company’s pipeline includes therapeutic candidates targeting pain, inappetence, cancer, viral diseases, allergy and other serious medical conditions.  Aratana believes the development and commercialization of these therapeutics will permit veterinarians and pet owners to manage pets’ medical needs safely and effectively, resulting in longer and improved quality of life for pets. For more information, please visit www.aratana.com.

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